Biotin and derivatives
Medchemexpress LLC DBCO-PEG12-NHS ester | 2093934-94-0 | 96.12% | C50H71N3O18 | 100 MG
DBCO-PEG12-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, utilizing a DBCO group to facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Enables synthesis of PROTACs
- Functions as a click chemistry reagent
- Utilizes DBCO group for SPAAC with azide-containing molecules
- Supports selective degradation of target proteins
Biotium Biotinylation Reagents Fluorescent Proteins Nucleotides Other Conjugates Biotin and Streptavidin Conjugates Biotin 1/EA
Biotin-cAMP diisopropylethylammonium salt is a biotin-conjugated cAMP analog thatcan be used to probe cAMP receptors ul liWhite lyophilized solid soluble in water Store at -20C and protect from light MW 826
Medchemexpress LLC Sulfo-Cyanine7 NHS ester potassium | 1603861-95-5 | 90.0% | 10 MG
Sulfo-Cyanine7 NHS ester potassium is a water-soluble, amine-reactive N-hydroxysuccinimide (NHS) ester of a near-infrared cyanine dye supplied as the potassium salt. It is used to label primary amines on proteins, peptides, and other biomolecules to produce sulfo-Cyanine7-labeled conjugates for near-IR fluorescence imaging and related research applications.
- Water-soluble near-infrared fluorescent dye.
- Amine-reactive NHS ester for efficient conjugation to proteins.
- Supplied as the potassium salt for enhanced solubility.
- Suitable for labeling proteins, peptides, and other biomolecules.
- Produces stable, near-IR fluorescent conjugates for imaging applications.
Medchemexpress LLC Biotin-TEG-ATFBA | 1264662-85-2 | C27H37F4N7O6S | 25 MG
Biotin-TEG-ATFBA is a click chemistry reagent that incorporates a perfluorophenylazide group. This reagent forms a highly stable azene intermediate which undergoes insertion and addition reactions (non-intermolecular rearrangement) in moderate to good yields after photolysis. It also has an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. Additionally, it can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. It is intended for research use only.
- Contains a perfluorophenylazide group
- Forms a highly stable azene intermediate upon photolysis
- Undergoes insertion and addition reactions
- Features an azide group for CuAAc with alkyne-containing molecules
- Can undergo SPAAC with DBCO or BCN groups
Medchemexpress LLC Biotin-PEG8-amine | 2183447-27-8 | 99.8% | C28H54N4O10S | 250 MG
Biotin-PEG8-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled, PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- For research use only.
- Appearance: solid, white to off-white.
Medchemexpress LLC Biotin-LC-LC-NHS | 89889-52-1 | 98.0% | 567.7 g/mol | C26H41N5O7S | 50 MG
Biotin-LC-LC-NHS is a long-chain N-hydroxysuccinimide (NHS) activated biotinylation reagent used to label proteins, antibodies, and small molecules. The LC-LC spacer reduces steric hindrance during conjugation, and the NHS ester reacts with primary amines to form stable amide bonds.
- Provides long-chain spacer (LC-LC) to reduce steric hindrance.
- Reactive NHS ester for amine-selective conjugation.
- Suitable for labeling antibodies and small molecules.
- Solid, white to light yellow appearance; store under inert gas and protect from light.
- Soluble in DMSO; follow recommended solvent and storage guidance.
Medchemexpress LLC DOTA-NHS-ester | 170908-81-3 | 501.49 g/mol | C20H31N5O10 | 1 G
DOTA-NHS-ester is an amine-reactive DOTA derivative (N-hydroxysuccinimide ester) used to conjugate chelators to peptides, proteins, and other biomolecules for radiolabeling and imaging probe preparation in PET and SPECT studies. It has formula C20H31N5O10 and molecular weight 501.49 g/mol. Manufacturer documents such as a datasheet, SDS, and COA are available.
- Amine-reactive NHS-ester for conjugation.
- Suitable for radiolabeling and imaging probe preparation.
- Chelator compatible with common radiometals.
- Molecular weight 501.49 g/mol.
- CAS number 170908-81-3.
- Supplied in research pack sizes including 1 g.
Medchemexpress LLC Bis-PEG9-NHS ester 500mg | 1008402-79-6 | 708.71 | C30H48N2O17 | 500 MG
Bis-PEG9-NHS ester is a PEG9-based bifunctional linker bearing two N-hydroxysuccinimide (NHS) ester groups, designed for amine-targeted bioconjugation and linker applications such as PROTAC and ADC synthesis. It provides a hydrophilic spacer to improve solubility and reduce aggregation during conjugation.
- Bifunctional amine-reactive crosslinker with two NHS ester groups.
- PEG9 spacer increases hydrophilicity and solubility in aqueous media.
- Suitable for PROTAC, ADC, and general bioconjugation to primary amines.
- High chemical purity (≥98%) for reliable conjugation performance.
- Viscous, colorless to light yellow material; moisture sensitive - store sealed and protected from moisture.
- Molecular weight ≈ 708.71 g/mol; molecular formula C30H48N2O17.
eMolecules Mal-PEG11-alcohol | Broadpharm |581.656 | C26H47NO13 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O | 1g | 599128887
Mal-PEG11-alcohol | Broadpharm |581.656 | C26H47NO13 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O | 1g | 599128887
Medchemexpress LLC Nsp-dmae-nhs | 194357-64-7 | 99.5% | 1 MG
NSP-DMAE-NHS is an acridinium ester chemiluminescence reagent containing an N-sulfopropyl group. It is useful in the clinical diagnostics industry, especially in automated immunochemistry analyzers. The product is for research use only and not sold to patients.
- Acridinium ester chemiluminescence reagent
- Contains n-sulfopropyl group
- Useful in the clinical diagnostics industry
- Applicable in automated immunochemistry analyzers
Medchemexpress LLC Ovalbumin-Biotin | 98.0% | 1 ML
Ovalbumin-Biotin is a biotinylated biochemical reagent utilized in research to label or detect specific antigens, molecules, or cellular structures.
- Purity: 98.0%
- Appearance: Liquid
- Color: Colorless to light yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Store under recommended conditions in the Certificate of Analysis
Sigma Aldrich Fine Chemicals Biosciences Biotin disulfide N-hydroxysuccinimide ester >98%, powder | Purity: >98% | Mol Wt: 575.72 | 142439-92-7 | MFCD00466919 | 100MG
Biotin disulfide N-hydroxysuccinimide ester >98%, powder | Purity: >98% | Mol Wt: 575.72 | 142439-92-7 | MFCD00466919 | 100MG
Medchemexpress LLC Biotinamidocaproyl hydrazide | 109276-34-8 | MFCD00077659 | 99.8% | 371.50 g/mol | C16H29N5O3S | 10 MG
Biotin LC hydrazide is a long-chain biotinylation reagent used to derivatize periodate-oxidized carbohydrates on glycoproteins and other biomolecules. The hydrazide moiety reacts with aldehydes generated by mild oxidation to form stable hydrazone linkages, while the long-chain spacer arm improves accessibility for detection and affinity capture. Intended for research use only.
- Reacts with periodate-oxidized carbohydrates and glycoproteins.
- Introduces a biotin tag via hydrazide chemistry for avidin/streptavidin detection.
- Long-chain spacer reduces steric hindrance and improves binding accessibility.
- Suitable for labeling, detection, and affinity purification workflows.
- Provided as a stable white solid for easy handling and storage.
Medchemexpress LLC 5-maleimido-pentanoic N-hydroxysuccinimide ester | 103750-03-4 | MFCD01318603 | 99.3% | 294.26 g/mol | C13H14N2O6 | 50 MG
Mal-C2-NHS ester (5-maleimido-pentanoic N-hydroxysuccinimide ester) is a noncleavable antibody-drug conjugate (ADC) linker that features a maleimide and an N-hydroxysuccinimide (NHS) ester for bioconjugation to thiol and amine groups during ADC synthesis.
- Noncleavable ADC linker suitable for antibody-drug conjugation.
- Maleimide group enables selective thiol coupling.
- N-hydroxysuccinimide (NHS) ester enables amine coupling.
- High purity and defined molecular weight for reproducible conjugation.
Medchemexpress LLC Biotin alkyne | 773888-45-2 | 99.53% | 281.37 | 25 MG
Biotin alkyne is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. PROTACs themselves are compounds utilizing two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein, to exploit the intracellular ubiquitin-proteasome system for selective protein degradation. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups